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Endocrine Abstracts

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ea0016s17.4 | Thyroid cell biology | ECE2008

Novel insights on the Na+/I− symporter (NIS): it mediates electroneutral active transport of the environmental pollutant perchlorate

Dohan O , Portulano C , Basquin C , Paroder M , Nicola JP , Maestas MJ , Eskandari S , Reyna-Neyra A , Amzel LM , Carrasco N

The Na+/I− symporter (NIS) is a key plasma membrane protein that mediates active I− uptake in the thyroid, lactating breast, and other tissues with an electrogenic stoichiometry of 2 Na+ per I−. In the thyroid, NIS-mediated I− uptake is the first step in the biosynthesis of the iodine-containing thyroid hormones, which are essential early in life for proper development of the central nerv...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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